Genistein attenuates peritoneal metastasis of azoxymethane-induced intestinal adenocarcinomas in Wistar rats
نویسندگان
چکیده
منابع مشابه
Suppression by verapamil of bombesin-enhanced peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in wistar rats.
BACKGROUND The effects of combined administration of bombesin and verapamil hydrochloride (verapamil), a calcium channel blocker, on the incidence of peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane (AOM) and the labeling index of intestinal cancers were investigated in male Wistar rats. METHODS From the beginning of the experiment, rats were given 10 weekly subcuta...
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Acute subcutaneous administration of angiotensin-II (Ang II-150μg/kg) causes a rise in blood pressure in normal Wistar rats. Administration of Punica granatum juice extract (PJ100 mg/kg and 300 mg/kg; p.o.) for 4 weeks in angiotensin-II treated rats significantly (P<0.05) reduced the mean arterial blood pressure and vascular reactivity changes to various catecholamines. PJ treatment significant...
متن کاملPromotion of azoxymethane-induced intestinal cancer by high-fat diet in rats.
Promotional properties of a high-fat diet in intestinal cancer were studied by feeding a 30% beef fat diet to 8 groups of rats (25 rats/group) for time periods varying from 1 to 21 weeks after 8 weekly s.c. injections of azoxymethane (AOM) (8 mg/ kg). Two other groups were fed the high-fat diet, one for 8 weeks prior to and the other during AOM injections. A 5% fat diet was fed to rats when not...
متن کاملGenistein Attenuates Vascular Endothelial Impairment in Ovariectomized Hyperhomocysteinemic Rats
Hyperhomocysteinemia (HHcy) is a well-known independent risk factor for vascular diseases in the general population. This study was to explore the effect of genistein (GST), a natural bioactive compound derived from legumes, on HHcy-induced vascular endothelial impairment in ovariectomized rats in vivo. Thirty-two adult female Wistar rats were assigned randomly into four groups (n = 8): (a) Con...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2000
ISSN: 0020-7136,1097-0215
DOI: 10.1002/(sici)1097-0215(20000501)86:3<416::aid-ijc17>3.3.co;2-r